Trichloroethanol (TCE), urine
Alternate test name
Chloral Hydrate
Lab area
Clinical Biochemistry - TDM & Toxicology
Method and equipment
GC-ECD
Expected turn-around time
Stat: 4 hours
Routine: 24 hours
Specimen type
Serum, Plasma (Heparin, Citrate or EDTA), Urine, Miscellaneous Fluid(s)*
Specimen requirements
1.0 mL
Storage and transportation
4°C (transport with a cool pack if possible)
Special requirements
* Miscellaneous Fluid(s): phone Toxicology Laboratory (416-813-5906) for availability on specific fluid.
Background and clinical significance
Chloral hydrate is a sedative and hypnotic drug, also known as trichloroacetaldehyde monohydrate, 2,2,2-trichloro-1,1-ethanediol. It is used for the short-term treatment of insomnia and as a sedative before minor medical or dental treatment. It has been largely displaced by the development of benzodiazepines. It was also formerly used as in veterinary medicine as a general anesthetic. Insomnia is a sleep disorder characterized by an inability to sleep and/or to remain asleep for a reasonable period during the night. Benzodiazepine tablets, the benzodiazepines, are a class of drugs with hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. Anesthesia (AE), also anesthesia (BE), is the process of blocking the perception of pain and other sensations. In therapeutic doses for insomnia it is effective within 60 minutes; it's rapidly metabolized into trichloroethanol and trichloroacetic acid. Higher doses can depress respiration and blood presure. An overdose is marked by confusion, convulsions, nausea, and vomiting, severe drowsiness, slow and irregular breathing, cardiac arrythmia and weakness. It may also cause liver damage. It is moderately addictive. Chronic use can cause dependency and withdrawals symptoms. A solution of chloral hydrate in alcohol is called "knockout drops" known as a Mickey Finn.
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